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Last Edit: 15/04/2025, PSI Villigen For questions, edit requests or interest, contact [email protected] and/or [email protected]
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In radiotherapy, the emergence of Ultra-High Dose Rate (UHDR) proton irradiation, or FLASH therapy, has gained significant attention for its potential to facilitate treatment modalities. In this work, we present a database derived from a meticulous study of FLASH studies. We aimed to create an easily navigable repository summarising current research and facilitating comparative assessments across experimental procedures and outcomes.
We collected all published papers until March 2024 about FLASH murine studies that directly compared CONV vs UHDR in all irradiation modalities (electrons, protons, carbons and X-rays). The database is continuously updated with new publications. Each experiment's physical and biological parameters must be extracted and listed in the database. Most parameters were documented within the papers; however, specific parameters were not directly provided and required calculations or extraction from plots. The additional information below gives explanations for the calculation and the parameters reported.
With this database, we want to provide a comprehensive overview of FLASH experiments, enabling comparisons of physical and biological parameters across studies. We also want to offer valuable insights for researchers initiating new experiments, potentially helping to reduce endpoint and methodology heterogeneity.
If you need help in using this database, check the video: https://drive.switch.ch/index.php/s/mxDcuEmx6KZScrp How to use the Notion Database
Skin toxicity - scale conversion
For specific endpoints, we extracted and reported all information into spreadsheets that can be easily used for statistical analysis with any programming language.
https://drive.switch.ch/index.php/s/eqRoZ2v859GcBUb Extracted Data for GUT irradiation
https://drive.switch.ch/index.php/s/GfWjaUfRLN1Sim8 Extracted Data for SKIN irradiation
Additionally, we provide the Python scripts used for simple endpoint comparisons:
Data extracted for single endpoints
Poster #819 PTCOG62: Unveiling Variability in pFLASH Mice Experiments: Towards a Comprehensive Understanding
Presentation in the PTCOG62 plenary session: Open Source Thinking: The Future of Data Sharing for Medical Research
FRPT 2024: Scoping Review of In Vivo FLASH Studies: Understanding Endpoints and Results Variability